Genius: An Automated System for Assigning Genome ORFs to 3D Structures, Using a Novel Multiple Intermediate Sequence Search
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منابع مشابه
GENIUS II: a high-throughput database system for linking ORFs in complete genomes to known protein three-dimensional structures
GENIUS II is an automated database system in which open reading frames (ORFs) in complete genomes are assigned to known protein three-dimensional (3D) structures. The system uses the multiple intermediate sequence search method in which query and target sequences are linked by intermediate sequences gathered by PSI-BLAST search. By applying the system to 129 complete genomes, 43.8% on average o...
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Several attempts to provide a completely automated procedure for genome analysis categorize the hits to globular domains into those matching a sequence of known three dimensional structure. Based only on standard sequence searching procedures such as FASTA, BLAST, complete genomes have currently been analyzed and 10-20% of the ORF sequences linked to a domain of known structure [1,2]. More Rece...
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تاریخ انتشار 2000